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Impact of Continuous Positive Airway Pressure Treatment on Left Ventricular Ejection Fraction in Patients with Obstructive Sleep Apnea: A Meta-Analysis of Randomized Controlled Trials

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  • Hao Sun
  • Jingpu Shi
  • Min Li
  • Xin Chen

Abstract

Background: It has been known for a long time that obstructive sleep apnea (OSA) is associated with a decreased left ventricular ejection fraction (LVEF). Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; however, it is unknown whether or not CPAP treatment will improve the LVEF. The aim of the current study was to assess whether or not CPAP treatment improves the LVEF. A meta-analysis was conducted to determine the effect of CPAP treatment on the LVEF among patients with OSA. Methods: A literature search of PubMed, the Web of Science, and Cochrane Collaboration’s database were utilized to identify eligible reports for this trial. Ten randomized controlled trails were examined and the meta-analysis was performed using STATA 11. Results: A significant improvement in the LVEF was observed after CPAP treatment (weighted mean difference(WMD) = 3.59, 95% CI = 1.74–5.44; P

Suggested Citation

  • Hao Sun & Jingpu Shi & Min Li & Xin Chen, 2013. "Impact of Continuous Positive Airway Pressure Treatment on Left Ventricular Ejection Fraction in Patients with Obstructive Sleep Apnea: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
    • Handle: RePEc:plo:pone00:0062298
    DOI: 10.1371/journal.pone.0062298
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