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Total Plasma Protein in Very Preterm Babies: Prognostic Value and Comparison with Illness Severity Scores

Author

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  • Silvia Iacobelli
  • Francesco Bonsante
  • Catherine Quantin
  • Pierre-Yves Robillard
  • Christine Binquet
  • Jean-Bernard Gouyon

Abstract

Objective: We aimed to investigate the predictive value for severe adverse outcome of plasma protein measurements on day one of life in very preterm infants and to compare total plasma protein levels with the validated illness severity scores CRIB, CRIB-II, SNAP-II and SNAPPE-II, regarding their predictive ability for severe adverse outcome. Methods: We analyzed a cohort of infants born at 24–31 weeks gestation, admitted to the tertiary intensive care unit of a university hospital over 10.5 years. The outcome measure was “severe adverse outcome” defined as death before discharge or severe neurological injury on cranial ultrasound. The adjusted odd ratio (aOR) and 95% confidence interval (95% CI) of severe adverse outcome for hypoproteinemia (total plasma protein level

Suggested Citation

  • Silvia Iacobelli & Francesco Bonsante & Catherine Quantin & Pierre-Yves Robillard & Christine Binquet & Jean-Bernard Gouyon, 2013. "Total Plasma Protein in Very Preterm Babies: Prognostic Value and Comparison with Illness Severity Scores," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0062210
    DOI: 10.1371/journal.pone.0062210
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