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GSTT1 Null Genotype Contributes to Lung Cancer Risk in Asian Populations: A Meta-Analysis of 23 Studies

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  • Xin Yang
  • Man-Tang Qiu
  • Jing-Wen Hu
  • Xiao-xiao Wang
  • Feng Jiang
  • Rong Yin
  • Lin Xu

Abstract

Background: Genetic variation in glutathione S-transferases (GSTs) may contribute to lung cancer risk. Many studies have investigated the correlation between the Glutathione S-transferase T1 (GSTT1) null genotype and lung cancer risk in Asian population but yielded inconclusive results. Methodology/Principal Findings: We performed a meta-analysis of 23 studies including 4065 cases and 5390 controls. We assessed the strength of the association of GSTT1 with lung cancer risk and performed sub-group analyses by source of controls, smoking status, histological types, and sample size. A statistically significant correlation between GSTT1 null genotype and lung cancer in Asian population was observed (OR = 1.28, 95% CI = 1.10, 1.49; Pheterogeneity

Suggested Citation

  • Xin Yang & Man-Tang Qiu & Jing-Wen Hu & Xiao-xiao Wang & Feng Jiang & Rong Yin & Lin Xu, 2013. "GSTT1 Null Genotype Contributes to Lung Cancer Risk in Asian Populations: A Meta-Analysis of 23 Studies," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0062181
    DOI: 10.1371/journal.pone.0062181
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