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Cobalamin Analogues in Humans: A Study on Maternal and Cord Blood

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  • Tore Forsingdal Hardlei
  • Rima Obeid
  • Wolfgang Herrmann
  • Ebba Nexo

Abstract

Background: Haptocorrin (HC) carries cobalamin analogues (CorA), but whether CorA are produced in the body is unknown. All cobalamins (Cbl) to the foetus are delivered by the Cbl-specific protein transcobalamin (TC), and therefore analysis of cord serum for CorA may help to clarify the origin of CorA. Methods: HC-CorA were quantified in paired samples of cord serum from newborns and serum from mothers (n = 69). Results: The CorA-concentration was higher in cord serum (median = 380, range: 41–780 pmol/L) than in serum from the mothers (median = 160, range: 64–330 pmol/L), (p

Suggested Citation

  • Tore Forsingdal Hardlei & Rima Obeid & Wolfgang Herrmann & Ebba Nexo, 2013. "Cobalamin Analogues in Humans: A Study on Maternal and Cord Blood," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-4, April.
    • Handle: RePEc:plo:pone00:0061194
    DOI: 10.1371/journal.pone.0061194
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