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Intraoperative Cryoprecipitate Transfusion and Its Association with the Incidence of Biliary Complications after Liver Transplantation-A Retrospective Cohort Study

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Listed:
  • Shuang Liu
  • Junwei Fan
  • Xiaoliang Wang
  • Zijun Gong
  • Shuyun Wang
  • Li Huang
  • Tonghai Xing
  • Tao Li
  • Zhihai Peng
  • Xing Sun

Abstract

Background: Cryoprecipitate is largely used for acquired hypofibrinogenemia in the setting of massive hemorrhage in liver transplantation (LT). However, the influence of intraoperative cryoprecipitate transfusion on biliary complications (BC) after LT has not been studied in detail. Study Design and Methods: In a series of 356 adult patients who received their first LT, the causes of BC were retrospectively studied by multivariate logistic regression analysis. The clinical relationship between intraoperative cryoprecipitate transfusion and BC occurrence was studied through a retrospective cohort study in patients. All patients received follow-ups for one year, and, during the follow-up period, the time of BC occurrence and liver biopsies were recorded. Results: Intraoperative cryoprecipitate transfusion (RR = 3.46, 95% CI [1.72–6.97], P 8 h (RR = 4.24, 95% CI [2.28–7.92], P

Suggested Citation

  • Shuang Liu & Junwei Fan & Xiaoliang Wang & Zijun Gong & Shuyun Wang & Li Huang & Tonghai Xing & Tao Li & Zhihai Peng & Xing Sun, 2013. "Intraoperative Cryoprecipitate Transfusion and Its Association with the Incidence of Biliary Complications after Liver Transplantation-A Retrospective Cohort Study," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0060727
    DOI: 10.1371/journal.pone.0060727
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