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How Do Childhood Diagnoses of Type 1 Diabetes Cluster in Time?

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  • Colin R Muirhead
  • Timothy D Cheetham
  • Simon Court
  • Michael Begon
  • Richard J Q McNally

Abstract

Background: Previous studies have indicated that type 1 diabetes may have an infectious origin. The presence of temporal clustering—an irregular temporal distribution of cases—would provide additional evidence that occurrence may be linked with an agent that displays epidemicity. We tested for the presence and form of temporal clustering using population-based data from northeast England. Materials and Methods: The study analysed data on children aged 0–14 years diagnosed with type 1 diabetes during the period 1990–2007 and resident in a defined geographical region of northeast England (Northumberland, Newcastle upon Tyne, and North Tyneside). Tests for temporal clustering by time of diagnosis were applied using a modified version of the Potthoff-Whittinghill method. Results: The study analysed 468 cases of children diagnosed with type 1 diabetes. There was highly statistically significant evidence of temporal clustering over periods of a few months and over longer time intervals (p

Suggested Citation

  • Colin R Muirhead & Timothy D Cheetham & Simon Court & Michael Begon & Richard J Q McNally, 2013. "How Do Childhood Diagnoses of Type 1 Diabetes Cluster in Time?," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0060489
    DOI: 10.1371/journal.pone.0060489
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