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Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases

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  • Wen-Feng Gong
  • Jian-Hong Zhong
  • Bang-De Xiang
  • Liang Ma
  • Xue-Mei You
  • Qiu-Ming Zhang
  • Le-Qun Li

Abstract

Background: The onset and progression of breast cancer (BC) is influenced by many factors, including the single nucleotide polymorphism (SNP) rs13281615 at 8q24. However, studies of the potential association between rs13281615 at 8q24 and risk of BC have given inconsistent results. We performed a meta-analysis to address this controversy. Methods: PubMed, EMBASE and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Two curators independently extracted data, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association between rs13281615 at 8q24 and risk of BC. Results: Fourteen studies are included in the meta-analysis, involving 44,283 cases (5,170 Chinese and 39,113 mixed) and 55,756 controls (5,589 Chinese and 50,167 mixed). The GG and G-allele genotypes of rs13281615 at 8q24 are significantly associated with increased risk of BC (GG vs. AG+AA, OR 1.13, 95% CI 1.08–1.19, P

Suggested Citation

  • Wen-Feng Gong & Jian-Hong Zhong & Bang-De Xiang & Liang Ma & Xue-Mei You & Qiu-Ming Zhang & Le-Qun Li, 2013. "Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0060108
    DOI: 10.1371/journal.pone.0060108
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    1. Noel Pabalan & Hamdi Jarjanazi & Lillian Sung & Hong Li & Hilmi Ozcelik, 2012. "Menopausal Status Modifies Breast Cancer Risk Associated with the Myeloperoxidase (MPO) G463A Polymorphism in Caucasian Women: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-7, March.
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