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Increased Expression of Pregnancy Up-Regulated Non-Ubiquitous Calmodulin Kinase Is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma

Author

Listed:
  • Song Wu
  • Zhaojie Lv
  • Yong Wang
  • Liang Sun
  • Zhimao Jiang
  • Congjie Xu
  • Jun Zhao
  • Xiaojuan Sun
  • Xianxin Li
  • Lijun Hu
  • Aifa Tang
  • Yaoting Gui
  • Fangjian Zhou
  • Zhiming Cai
  • Rongfu Wang

Abstract

Purpose: The aims of this study were to evaluate the clinical significance and potential prognostic value of pregnancy up-regulated non-ubiquitous calmodulin kinase (PNCK) in clear cell renal cell carcinoma (ccRCC) patients. Materials and Methods: The expression of PNCK mRNA was determined in 24 paired samples of ccRCCs and adjacent normal tissues using real-time RT-PCR. The expression of PNCK was determined in 248 samples of ccRCCs and 92 paired samples of adjacent normal tissues by immunohistochemical analysis. Statistical analysis was performed to define the relationship between PNCK expression and the clinical features of ccRCC. Results: The mRNA level of PNCK was significantly higher in tumorous tissues than in the adjacent non-tumorous tissues (p

Suggested Citation

  • Song Wu & Zhaojie Lv & Yong Wang & Liang Sun & Zhimao Jiang & Congjie Xu & Jun Zhao & Xiaojuan Sun & Xianxin Li & Lijun Hu & Aifa Tang & Yaoting Gui & Fangjian Zhou & Zhiming Cai & Rongfu Wang, 2013. "Increased Expression of Pregnancy Up-Regulated Non-Ubiquitous Calmodulin Kinase Is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0059936
    DOI: 10.1371/journal.pone.0059936
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