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Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population

Author

Listed:
  • Wan C Tan
  • Jean Bourbeau
  • Paul Hernandez
  • Kenneth R Chapman
  • Robert Cowie
  • J Mark FitzGerald
  • Shawn Aaron
  • Darcy D Marciniuk
  • Francois Maltais
  • A Sonia Buist
  • Denis E O’Donnell
  • Don D Sin

Abstract

Background: The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. Aim: To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. Methods: 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered respiratory questionnaires and performed spirometry before and after administration of 200 ug of inhaled salbutamol. The effect of anthropometric variables, smoking exposure and doctor-diagnosed asthma (DDA) on bronchodilator responsiveness in forced expiratory volume in 1 second (FEV1) and in forced vital capacity (FVC) were evaluated. Multiple logistic regression was used to test for association between quintiles of increasing changes in FEV1 and in FVC after bronchodilator and several respiratory symptoms. Results: Determinants of bronchodilator change in FEV1 and FVC included age, DDA, smoking, respiratory drug use and female gender [p

Suggested Citation

  • Wan C Tan & Jean Bourbeau & Paul Hernandez & Kenneth R Chapman & Robert Cowie & J Mark FitzGerald & Shawn Aaron & Darcy D Marciniuk & Francois Maltais & A Sonia Buist & Denis E O’Donnell & Don D Sin, 2013. "Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
  • Handle: RePEc:plo:pone00:0058932
    DOI: 10.1371/journal.pone.0058932
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