IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0056179.html
   My bibliography  Save this article

Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene

Author

Listed:
  • Blanca E Himes
  • Keith Sheppard
  • Annerose Berndt
  • Adriana S Leme
  • Rachel A Myers
  • Christopher R Gignoux
  • Albert M Levin
  • W James Gauderman
  • James J Yang
  • Rasika A Mathias
  • Isabelle Romieu
  • Dara G Torgerson
  • Lindsey A Roth
  • Scott Huntsman
  • Celeste Eng
  • Barbara Klanderman
  • John Ziniti
  • Jody Senter-Sylvia
  • Stanley J Szefler
  • Robert F Lemanske Jr
  • Robert S Zeiger
  • Robert C Strunk
  • Fernando D Martinez
  • Homer Boushey
  • Vernon M Chinchilli
  • Elliot Israel
  • David Mauger
  • Gerard H Koppelman
  • Dirkje S Postma
  • Maartje A E Nieuwenhuis
  • Judith M Vonk
  • John J Lima
  • Charles G Irvin
  • Stephen P Peters
  • Michiaki Kubo
  • Mayumi Tamari
  • Yusuke Nakamura
  • Augusto A Litonjua
  • Kelan G Tantisira
  • Benjamin A Raby
  • Eugene R Bleecker
  • Deborah A Meyers
  • Stephanie J London
  • Kathleen C Barnes
  • Frank D Gilliland
  • L Keoki Williams
  • Esteban G Burchard
  • Dan L Nicolae
  • Carole Ober
  • Dawn L DeMeo
  • Edwin K Silverman
  • Beverly Paigen
  • Gary Churchill
  • Steve D Shapiro
  • Scott T Weiss

Abstract

Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-related phenotypes. Our goal was to identify asthma-related genes by integrating AHR associations in mouse with human genome-wide association study (GWAS) data. We used Efficient Mixed Model Association (EMMA) analysis to conduct a GWAS of baseline AHR measures from males and females of 31 mouse strains. Genes near or containing SNPs with EMMA p-values

Suggested Citation

  • Blanca E Himes & Keith Sheppard & Annerose Berndt & Adriana S Leme & Rachel A Myers & Christopher R Gignoux & Albert M Levin & W James Gauderman & James J Yang & Rasika A Mathias & Isabelle Romieu & D, 2013. "Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0056179
    DOI: 10.1371/journal.pone.0056179
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0056179
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0056179&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0056179?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0056179. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.