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Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease

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  • Fan-Chi Chang
  • Tai-Shuan Lai
  • Chih-Kang Chiang
  • Yung-Ming Chen
  • Ming-Shiou Wu
  • Tzong-Shinn Chu
  • Kwan-Dun Wu
  • Shuei-Liong Lin

Abstract

Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and mortality in CKD patients, we were intrigued by the relationship between albuminuria and angiopoietin-2. A total of 416 patients with CKD stages 3 to 5 were stratified by urine albumin-creatinine ratio as normoalbuminuria ( 300 mg/g). The levels of plasma angiopoietin-2 and vascular endothelial growth factor (VEGF) increased, and soluble Tie-2 decreased in the subgroups of albuminuria; whereas angiopoietin-1 did not change. Linear regression showed a positive correlation between urine albumin-creatinine ratio (ACR) and plasma angiopoietin-2 (correlation coefficient r = 0.301, 95% confidence interval 0.211–0.386, P

Suggested Citation

  • Fan-Chi Chang & Tai-Shuan Lai & Chih-Kang Chiang & Yung-Ming Chen & Ming-Shiou Wu & Tzong-Shinn Chu & Kwan-Dun Wu & Shuei-Liong Lin, 2013. "Angiopoietin-2 Is Associated with Albuminuria and Microinflammation in Chronic Kidney Disease," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-6, March.
    • Handle: RePEc:plo:pone00:0054668
    DOI: 10.1371/journal.pone.0054668
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