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Role of Vaspin in Human Eating Behaviour

Author

Listed:
  • Jana Breitfeld
  • Anke Tönjes
  • Marie-Therese Gast
  • Dorit Schleinitz
  • Matthias Blüher
  • Michael Stumvoll
  • Peter Kovacs
  • Yvonne Böttcher

Abstract

Objective: The adipokine vaspin (visceral adipose tissue derived serine protease inhibitor, serpinA12) follows a meal-related diurnal variation in humans and intracerebroventricular vaspin administration leads to acutely reduced food intake in db/db mice. We therefore hypothesized that vaspin may play a role in human eating behaviour. Materials and Methods: We measured serum vaspin concentrations in 548 subjects from a self-contained population of Sorbs (Germany) who underwent detailed metabolic testing including eating behaviour assessments using the three-factor eating questionnaire. In addition, genetic variation within vaspin was assessed by genotyping 28 single nucleotide polymorphisms (SNPs) in all study subjects. Results: Serum vaspin concentrations correlated positively with restraint, disinhibition and hunger (all P 0.05). Independent of observed correlations, genetic variants in vaspin were associated with serum vaspin levels but showed no significant association with any of the eating behaviour phenotypes after accounting for multiple testing (P≥0.05 after adjusting for age, gender and BMI). Conclusion: Our data suggest that serum vaspin concentrations might modulate human eating behaviour, which does not seem to be affected by common genetic variation in vaspin.

Suggested Citation

  • Jana Breitfeld & Anke Tönjes & Marie-Therese Gast & Dorit Schleinitz & Matthias Blüher & Michael Stumvoll & Peter Kovacs & Yvonne Böttcher, 2013. "Role of Vaspin in Human Eating Behaviour," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-5, January.
    • Handle: RePEc:plo:pone00:0054140
    DOI: 10.1371/journal.pone.0054140
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