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Spirometry Reference Equations for Central European Populations from School Age to Old Age

Author

Listed:
  • Mascha K Rochat
  • Ruediger P Laubender
  • Daniela Kuster
  • Otto Braendli
  • Alexander Moeller
  • Ulrich Mansmann
  • Erika von Mutius
  • Johannes Wildhaber

Abstract

Background: Spirometry reference values are important for the interpretation of spirometry results. Reference values should be updated regularly, derived from a population as similar to the population for which they are to be used and span across all ages. Such spirometry reference equations are currently lacking for central European populations. Objective: To develop spirometry reference equations for central European populations between 8 and 90 years of age. Materials: We used data collected between January 1993 and December 2010 from a central European population. The data was modelled using “Generalized Additive Models for Location, Scale and Shape” (GAMLSS). Results: The spirometry reference equations were derived from 118'891 individuals consisting of 60'624 (51%) females and 58'267 (49%) males. Altogether, there were 18'211 (15.3%) children under the age of 18 years. Conclusion: We developed spirometry reference equations for a central European population between 8 and 90 years of age that can be implemented in a wide range of clinical settings.

Suggested Citation

  • Mascha K Rochat & Ruediger P Laubender & Daniela Kuster & Otto Braendli & Alexander Moeller & Ulrich Mansmann & Erika von Mutius & Johannes Wildhaber, 2013. "Spirometry Reference Equations for Central European Populations from School Age to Old Age," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
    • Handle: RePEc:plo:pone00:0052619
    DOI: 10.1371/journal.pone.0052619
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