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Progression to Type 2 Diabetes in Women with Former Gestational Diabetes: Time Trajectories of Metabolic Parameters

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  • Andrea Tura
  • Angela Grassi
  • Yvonne Winhofer
  • Annamaria Guolo
  • Giovanni Pacini
  • Andrea Mari
  • Alexandra Kautzky-Willer

Abstract

Aim of this study was analyzing the time trajectories of the metabolic parameters in European women with former gestational diabetes (fGDM), and determining predictors of type 2 diabetes onset. A group of seventy-six fGDM women were studied at the outpatient department of the University Clinic of Vienna. They were evaluated yearly with a 3 h-oral glucose tolerance test (OGTT) up to 7-years from delivery. At baseline, women also underwent an intravenous glucose tolerance test (IVGTT). Insulin sensitivity and beta-cell function were assessed by both OGTT and IVGTT. Women were divided into progressors (PROG) to diabetes (n = 19) and non-progressors (n = 57). Time trajectories of glycemia and other parameters were analyzed after synchronization to time of diabetes onset or last OGTT. Then, Cox proportional hazard regression analysis was performed to assess the predictive power of studied variables for diabetes onset. We found that, in PROG, time trajectories of glycemia were flat until diabetes onset, when they showed a marked increase (P

Suggested Citation

  • Andrea Tura & Angela Grassi & Yvonne Winhofer & Annamaria Guolo & Giovanni Pacini & Andrea Mari & Alexandra Kautzky-Willer, 2012. "Progression to Type 2 Diabetes in Women with Former Gestational Diabetes: Time Trajectories of Metabolic Parameters," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0050419
    DOI: 10.1371/journal.pone.0050419
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