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Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study

Author

Listed:
  • Fabio Lauria
  • Alfonso Siani
  • Karin Bammann
  • Ronja Foraita
  • Inge Huybrechts
  • Licia Iacoviello
  • Anna C Koni
  • Yannis Kourides
  • Staffan Marild
  • Denes Molnar
  • Luis A Moreno
  • Iris Pigeot
  • Yannis P Pitsiladis
  • Toomas Veidebaum
  • Paola Russo
  • IDEFICS Consortium

Abstract

Objectives: We investigated cross-sectionally and longitudinally the relationship between FTO rs9939609 and obesity-related characteristics in the European children of the IDEFICS project and the interaction of this variant with a lifestyle intervention. Population and Methods: A cohort of 16224 children (2–9 years) was recruited into a population-based survey (T0) from eight European countries. A second survey (T1) reassessed the children two years later. A random sample of 4405 children was extracted for genetic studies. 3168 children were re-examined two years later. Half of them underwent a lifestyle intervention program. The FTO rs9939609 was genotyped. Weight, height, waist circumference, triceps and subscapular skinfolds were measured at T0 and T1. Results: At T0, the risk A allele of rs9939609 was significantly associated with higher values of body mass index (BMI), waist circumference and skinfolds (age, sex, and country-adjusted p-values: all p

Suggested Citation

  • Fabio Lauria & Alfonso Siani & Karin Bammann & Ronja Foraita & Inge Huybrechts & Licia Iacoviello & Anna C Koni & Yannis Kourides & Staffan Marild & Denes Molnar & Luis A Moreno & Iris Pigeot & Yannis, 2012. "Prospective Analysis of the Association of a Common Variant of FTO (rs9939609) with Adiposity in Children: Results of the IDEFICS Study," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-6, November.
    • Handle: RePEc:plo:pone00:0048876
    DOI: 10.1371/journal.pone.0048876
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