IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0046982.html
   My bibliography  Save this article

Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies

Author

Listed:
  • Bingbing Wei
  • Zhuoqun Xu
  • You Zhou
  • Jun Ruan
  • Huan Cheng
  • Bo Xi
  • Ming Zhu
  • Ke Jin
  • Deqi Zhou
  • Qiang Hu
  • Qiang Wang
  • Zhirong Wang
  • Zhiqiang Yan
  • Feng Xuan
  • Xing Huang
  • Jian Zhang
  • Hongyi Zhou

Abstract

Background: Glutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis. Methodology/Principal Findings: A comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR = 1.28, 95% CI: 1.11–1.48, P = 0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR = 1.35, 95% CI: 1.03–1.78, P = 0.03) but not among Caucasians (OR = 1.12, 95% CI: 0.96–1.31, P = 0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa. Conclusions/Significance: The present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians.

Suggested Citation

  • Bingbing Wei & Zhuoqun Xu & You Zhou & Jun Ruan & Huan Cheng & Bo Xi & Ming Zhu & Ke Jin & Deqi Zhou & Qiang Hu & Qiang Wang & Zhirong Wang & Zhiqiang Yan & Feng Xuan & Xing Huang & Jian Zhang & Hongy, 2012. "Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0046982
    DOI: 10.1371/journal.pone.0046982
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046982
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046982&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0046982?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Rui Chen & Shancheng Ren & Tong Meng & Josephine Aguilar & Yinghao Sun, 2013. "Impact of Glutathione-S-Transferases (GST) Polymorphisms and Hypermethylation of Relevant Genes on Risk of Prostate Cancer Biochemical Recurrence: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-12, September.
    2. repec:plo:pone00:0078707 is not listed on IDEAS

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0046982. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.