IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0046691.html
   My bibliography  Save this article

Statin Use and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies

Author

Listed:
  • Dipika Bansal
  • Krishna Undela
  • Sanjay D'Cruz
  • Fabrizio Schifano

Abstract

Background: Emerging evidence suggests that statins may decrease the risk of cancers. However, available evidence on prostate cancer (PCa) is conflicting. We therefore examined the association between statin use and risk of PCa by conducting a detailed meta-analysis of all observational studies published regarding this subject. Methods: Literature search in PubMed database was undertaken through February 2012 looking for observational studies evaluating the association between statin use and risk of PCa. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated using random-effects model (DerSimonian and Laird method). Subgroup analyses, sensitivity analysis and cumulative meta-analysis were also performed. Results: A total of 27 (15 cohort and 12 case-control) studies contributed to the analysis. There was heterogeneity among the studies but no publication bias. Statin use significantly reduced the risk of both total PCa by 7% (RR 0.93, 95% CI 0.87–0.99, p = 0.03) and clinically important advanced PCa by 20% (RR 0.80, 95% CI 0.70–0.90, p

Suggested Citation

  • Dipika Bansal & Krishna Undela & Sanjay D'Cruz & Fabrizio Schifano, 2012. "Statin Use and Risk of Prostate Cancer: A Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0046691
    DOI: 10.1371/journal.pone.0046691
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046691
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0046691&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0046691?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiao Yi & Wei Jia & Yin Jin & Shang Zhen, 2014. "Statin Use Is Associated with Reduced Risk of Haematological Malignancies: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
    2. Yan-bo Chen & Qi Chen & Zhong Wang & Juan Zhou, 2013. "Insulin Therapy and Risk of Prostate Cancer: a Systematic Review and Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    3. Jinliang Wang & Cheng Li & Haitao Tao & Yao Cheng & Lu Han & Xiaoyan Li & Yi Hu, 2013. "Statin Use and Risk of Lung Cancer: a Meta-Analysis of Observational Studies and Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0046691. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.