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Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals

Author

Listed:
  • Fumihiko Takeuchi
  • Masato Isono
  • Tomohiro Katsuya
  • Mitsuhiro Yokota
  • Ken Yamamoto
  • Toru Nabika
  • Kazuro Shimokawa
  • Eitaro Nakashima
  • Takao Sugiyama
  • Hiromi Rakugi
  • Shuhei Yamaguchi
  • Toshio Ogihara
  • Yukio Yamori
  • Norihiro Kato

Abstract

Background/Objective: In Japanese populations, we performed a replication study of genetic loci previously identified in European-descent populations as being associated with lipid levels and risk of coronary artery disease (CAD). Methods: We genotyped 48 single nucleotide polymorphisms (SNPs) from 22 candidate loci that had previously been identified by genome-wide association (GWA) meta-analyses for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and/or triglycerides in Europeans. We selected 22 loci with 2 parallel tracks from 95 reported loci: 16 significant loci (p

Suggested Citation

  • Fumihiko Takeuchi & Masato Isono & Tomohiro Katsuya & Mitsuhiro Yokota & Ken Yamamoto & Toru Nabika & Kazuro Shimokawa & Eitaro Nakashima & Takao Sugiyama & Hiromi Rakugi & Shuhei Yamaguchi & Toshio O, 2012. "Association of Genetic Variants Influencing Lipid Levels with Coronary Artery Disease in Japanese Individuals," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0046385
    DOI: 10.1371/journal.pone.0046385
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