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Reproducibility and Respiratory Function Correlates of Exhaled Breath Fingerprint in Chronic Obstructive Pulmonary Disease

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Listed:
  • Raffaele Antonelli Incalzi
  • Giorgio Pennazza
  • Simone Scarlata
  • Marco Santonico
  • Massimo Petriaggi
  • Domenica Chiurco
  • Claudio Pedone
  • Arnaldo
  • D'Amico

Abstract

Background: The electronic nose (e nose) provides distinctive breath fingerprints for selected respiratory diseases. Both reproducibility and respiratory function correlates of breath fingerprint are poorly known. Objectives: To measure reproducibility of breath fingerprints and to assess their correlates among respiratory function indexes in elderly healthy and COPD subjects. Method: 25 subjects (5 COPD patients for each GOLD stage and 5 healthy controls) over 65 years underwent e-nose study through a seven sensor system and respiratory function tests at times 0, 7, and 15 days. Reproducibility of the e nose pattern was computed. The correlation between volatile organic compound (VOC) pattern and respiratory function/clinical parameters was assessed by the Spearman's rho. Measurements and Main Results: VOC patterns were highly reproducible within healthy and GOLD 4 COPD subjects, less among GOLD 1–3 patients.VOC patterns significantly correlated with expiratory flows (Spearman's rho ranging from 0.36 for MEF25% and sensor Co-Buti-TPP, to 0.81 for FEV1% and sensor Cu-Buti-TPP p

Suggested Citation

  • Raffaele Antonelli Incalzi & Giorgio Pennazza & Simone Scarlata & Marco Santonico & Massimo Petriaggi & Domenica Chiurco & Claudio Pedone & Arnaldo & D'Amico, 2012. "Reproducibility and Respiratory Function Correlates of Exhaled Breath Fingerprint in Chronic Obstructive Pulmonary Disease," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-8, October.
    • Handle: RePEc:plo:pone00:0045396
    DOI: 10.1371/journal.pone.0045396
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