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Bradykinin β2 Receptor −58T/C Gene Polymorphism and Essential Hypertension: A Meta-Analysis

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Listed:
  • Yan-yan Li
  • Hui Zhang
  • Jian Xu
  • Yun Qian
  • Xin-zheng Lu
  • Bing Yang
  • Minglong Chen
  • Zhi-jian Yang
  • Ke-jiang Cao

Abstract

Background: Research has shown that bradykinin β2 receptor (BDKRB2) −58T/C gene polymorphism is correlated with the risk of essential hypertension (EH), but the results remain inconclusive. Objective and Methods: The objective of this study was to explore the association between BDKRB2−58T/C gene polymorphism and EH. A meta-analysis of 11 studies with 3882 subjects was conducted. Pooled odds ratios (ORs) for the association between BDKRB2−58T/C gene polymorphism and EH and their corresponding 95% confidence intervals (CIs) were estimated using the random effects model. Results: The BDKRB2−58T/C gene polymorphism was significantly correlated with EH under an allelic genetic model (OR = 1.24, 95% CI = 1.05–1.46; P = 0.01), a dominant genetic model (OR = 0.65, 95% CI = 0.47–0.90; P = 0.01), a recessive genetic model (OR = 1.146, 95% CI = 1.035–1.269; P = 0.009), a homozygote genetic model (OR = 1.134, 95% CI = 1.048–1.228; P = 0.002), and a heterozygote genetic model (OR = 1.060, 95% CI = 1.009–1.112; P = 0.019). Conclusions: The BDKRB2−58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the −58C allele are susceptible to EH.

Suggested Citation

  • Yan-yan Li & Hui Zhang & Jian Xu & Yun Qian & Xin-zheng Lu & Bing Yang & Minglong Chen & Zhi-jian Yang & Ke-jiang Cao, 2012. "Bradykinin β2 Receptor −58T/C Gene Polymorphism and Essential Hypertension: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-6, August.
    • Handle: RePEc:plo:pone00:0043068
    DOI: 10.1371/journal.pone.0043068
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    1. Yan-yan Li, 2012. "α-Adducin Gly460Trp Gene Mutation and Essential Hypertension in a Chinese Population: A Meta-Analysis including 10960 Subjects," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-12, January.
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