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The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection

Author

Listed:
  • Gayle P Dolan
  • Puja R Myles
  • Stephen J Brett
  • Joanne E Enstone
  • Robert C Read
  • Peter J M Openshaw
  • Malcolm G Semple
  • Wei Shen Lim
  • Bruce L Taylor
  • James McMenamin
  • Karl G Nicholson
  • Barbara Bannister
  • Jonathan S Nguyen-Van-Tam
  • the Influenza Clinical Information Network (FLU-CIN)

Abstract

Introduction: The Influenza Clinical Information Network (FLU-CIN) was established to gather detailed clinical and epidemiological information about patients with laboratory confirmed A(H1N1)pdm09 infection in UK hospitals. This report focuses on the clinical course and outcomes of infection in pregnancy. Methods: A standardised data extraction form was used to obtain detailed clinical information from hospital case notes and electronic records, for patients with PCR-confirmed A(H1N1)pdm09 infection admitted to 13 sentinel hospitals in five clinical 'hubs' and a further 62 non-sentinel hospitals, between 11th May 2009 and 31st January 2010.Outcomes were compared for pregnant and non-pregnant women aged 15–44 years, using univariate and multivariable techniques. Results: Of the 395 women aged 15–44 years, 82 (21%) were pregnant; 73 (89%) in the second or third trimester. Pregnant women were significantly less likely to exhibit severe respiratory distress at initial assessment (OR = 0.49 (95% CI: 0.30–0.82)), require supplemental oxygen on admission (OR = 0.40 (95% CI: 0.20–0.80)), or have underlying co-morbidities (p-trend

Suggested Citation

  • Gayle P Dolan & Puja R Myles & Stephen J Brett & Joanne E Enstone & Robert C Read & Peter J M Openshaw & Malcolm G Semple & Wei Shen Lim & Bruce L Taylor & James McMenamin & Karl G Nicholson & Barbara, 2012. "The Comparative Clinical Course of Pregnant and Non-Pregnant Women Hospitalised with Influenza A(H1N1)pdm09 Infection," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-6, August.
    • Handle: RePEc:plo:pone00:0041638
    DOI: 10.1371/journal.pone.0041638
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