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Effects of Hyperuricemia on Renal Function of Renal Transplant Recipients: A Systematic Review and Meta-Analysis of Cohort Studies

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  • Yan Huang
  • Yu-Lin Li
  • He Huang
  • Ling Wang
  • Wen-Ming Yuan
  • Jing Li

Abstract

Background: Hyperuricemia is an independent risk factor of nephropathy, but its role in renal transplant recipients (RTRs) is controversial. Methods: Based on the methods of Cochrane systematic reviews, we searched MEDLINE (1948–2011.6), EMBASE (1956–2011.6), CBM (Chinese Biomedicine Database) (1978–2011.6) to identify cohort studies assessing the association between uric acid level and kidney allograft. Two authors independently screened the studies, assessed the risk of bias of included studies and extracted data. Unadjusted odds ratio(OR), mean difference (MD), adjusted hazard ratio (aHR) and their corresponding 95%CI were pooled to assess the effects of hyperuricemia on kidney allograft. Results: Twelve cohort studies were included and the quality was moderate to high based on the NEWCASTLE-OTTAWA quality assessment scale. RTRs with hyperuricemia had lower eGFR (P

Suggested Citation

  • Yan Huang & Yu-Lin Li & He Huang & Ling Wang & Wen-Ming Yuan & Jing Li, 2012. "Effects of Hyperuricemia on Renal Function of Renal Transplant Recipients: A Systematic Review and Meta-Analysis of Cohort Studies," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-7, June.
    • Handle: RePEc:plo:pone00:0039457
    DOI: 10.1371/journal.pone.0039457
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    1. Miyeun Han & Jung Pyo Lee & Seokwoo Park & Yunmi Kim & Yong Chul Kim & Curie Ahn & Duck Jong Han & Jongwon Ha & In Mok Jung & Chun Soo Lim & Yon Su Kim & Young Hoon Kim & Yun Kyu Oh, 2017. "Early onset hyperuricemia is a prognostic marker for kidney graft failure: Propensity score matching analysis in a Korean multicenter cohort," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-13, May.

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