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IL-6-174 G/C and -572 C/G Polymorphisms and Risk of Alzheimer’s Disease

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  • Hui-Ping Qi
  • Zheng-Yi Qu
  • Shu-Rong Duan
  • Shu-Qin Wei
  • Shi-Rong Wen
  • Sheng Bi

Abstract

Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer’s disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52–0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR = 0.73, 95% CI = 0.62–0.86) and in additive model (GG vs. CC, OR = 0.66, 95% CI = 0.46–0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.

Suggested Citation

  • Hui-Ping Qi & Zheng-Yi Qu & Shu-Rong Duan & Shu-Qin Wei & Shi-Rong Wen & Sheng Bi, 2012. "IL-6-174 G/C and -572 C/G Polymorphisms and Risk of Alzheimer’s Disease," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-6, June.
    • Handle: RePEc:plo:pone00:0037858
    DOI: 10.1371/journal.pone.0037858
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