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Bronchial Responsiveness Is Related to Increased Exhaled NO (FENO) in Non-Smokers and Decreased FENO in Smokers

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  • Andrei Malinovschi
  • Christer Janson
  • Marieann Högman
  • Giovanni Rolla
  • Kjell Torén
  • Dan Norbäck
  • Anna-Carin Olin

Abstract

Rationale: Both atopy and smoking are known to be associated with increased bronchial responsiveness. Fraction of nitric oxide (NO) in the exhaled air (FENO), a marker of airways inflammation, is decreased by smoking and increased by atopy. NO has also a physiological bronchodilating and bronchoprotective role. Objectives: To investigate how the relation between FENO and bronchial responsiveness is modulated by atopy and smoking habits. Methods: Exhaled NO measurements and methacholine challenge were performed in 468 subjects from the random sample of three European Community Respiratory Health Survey II centers: Turin (Italy), Gothenburg and Uppsala (both Sweden). Atopy status was defined by using specific IgE measurements while smoking status was questionnaire-assessed. Main Results: Increased bronchial responsiveness was associated with increased FENO levels in non-smokers (p = 0.02) and decreased FENO levels in current smokers (p = 0.03). The negative association between bronchial responsiveness and FENO was seen only in the group smoking less

Suggested Citation

  • Andrei Malinovschi & Christer Janson & Marieann Högman & Giovanni Rolla & Kjell Torén & Dan Norbäck & Anna-Carin Olin, 2012. "Bronchial Responsiveness Is Related to Increased Exhaled NO (FENO) in Non-Smokers and Decreased FENO in Smokers," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0035725
    DOI: 10.1371/journal.pone.0035725
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