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Evidence of Differential Allelic Effects between Adolescents and Adults for Plasma High-Density Lipoprotein

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  • Rita P S Middelberg
  • Andrew C Heath
  • Pamela A F Madden
  • Grant W Montgomery
  • Nicholas G Martin
  • John B Whitfield

Abstract

A recent meta-analysis of genome-wide association (GWA) studies identified 95 loci that influence lipid traits in the adult population and found that collectively these explained about 25–30% of heritability for each trait. Little is known about how these loci affect lipid levels in early life, but there is evidence that genetic effects on HDL- and LDL-cholesterol (HDL-C, LDL-C) and triglycerides vary with age. We studied Australian adults (N = 10,151) and adolescents (N = 2,363) who participated in twin and family studies and for whom we have lipid phenotypes and genotype information for 91 of the 95 genetic variants. Heterogeneity tests between effect sizes in adult and adolescent cohorts showed an excess of heterogeneity for HDL-C (pHet

Suggested Citation

  • Rita P S Middelberg & Andrew C Heath & Pamela A F Madden & Grant W Montgomery & Nicholas G Martin & John B Whitfield, 2012. "Evidence of Differential Allelic Effects between Adolescents and Adults for Plasma High-Density Lipoprotein," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0035605
    DOI: 10.1371/journal.pone.0035605
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