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1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation: Identification of Activity, Formulation, and Randomised, Controlled Trials

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  • Ian F Burgess
  • Peter N Lee
  • Katrina Kay
  • Ruth Jones
  • Elizabeth R Brunton

Abstract

Background: Interest in developing physically active pediculicides has identified new active substances. The objective was to evaluate a new treatment for clinical efficacy. Methods and Findings: We describe the selection of 1,2-octanediol as a potential pediculicide. Clinical studies were community based. The main outcome measure was no live lice, after two treatments, with follow up visits over 14 days. Conclusions: 1,2-octanediol was found to eliminate head louse infestation. It is believed to disrupt the insect's cuticular lipid, resulting in dehydration. The alcohol free mousse is more acceptable exhibiting significantly fewer adverse reactions. Trial registrations: Controlled-Trials.com ISRCTN66611560, ISRCTN91870666, ISRCTN28722846

Suggested Citation

  • Ian F Burgess & Peter N Lee & Katrina Kay & Ruth Jones & Elizabeth R Brunton, 2012. "1,2-Octanediol, a Novel Surfactant, for Treating Head Louse Infestation: Identification of Activity, Formulation, and Randomised, Controlled Trials," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-11, April.
    • Handle: RePEc:plo:pone00:0035419
    DOI: 10.1371/journal.pone.0035419
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