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Integrating Prevention of Mother-to-Child HIV Transmission Programs to Improve Uptake: A Systematic Review

Author

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  • Lorainne Tudor Car
  • Michelle H M M T Van Velthoven
  • Serena Brusamento
  • Hoda Elmoniry
  • Josip Car
  • Azeem Majeed
  • Peter Tugwell
  • Vivian Welch
  • Ana Marusic
  • Rifat Atun

Abstract

Background: We performed a systematic review to assess the effect of integrated perinatal prevention of mother-to-child transmission of HIV interventions compared to non- or partially integrated services on the uptake in low- and middle-income countries. Methods: We searched for experimental, quasi-experimental and controlled observational studies in any language from 21 databases and grey literature sources. Results: Out of 28 654 citations retrieved, five studies met our inclusion criteria. A cluster randomized controlled trial reported higher probability of nevirapine uptake at the labor wards implementing HIV testing and structured nevirapine adherence assessment (RRR 1.37, bootstrapped 95% CI, 1.04–1.77). A stepped wedge design study showed marked improvement in antiretroviral therapy (ART) enrolment (44.4% versus 25.3%, p

Suggested Citation

  • Lorainne Tudor Car & Michelle H M M T Van Velthoven & Serena Brusamento & Hoda Elmoniry & Josip Car & Azeem Majeed & Peter Tugwell & Vivian Welch & Ana Marusic & Rifat Atun, 2012. "Integrating Prevention of Mother-to-Child HIV Transmission Programs to Improve Uptake: A Systematic Review," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0035268
    DOI: 10.1371/journal.pone.0035268
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