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Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis

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  • SiJie Liu
  • ChuiJin Kong
  • Jie Wu
  • Hao Ying
  • HuanZhang Zhu

Abstract

Background: So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility. Methods: We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility. Results: Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88–1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71–1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping. Conclusions: The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.

Suggested Citation

  • SiJie Liu & ChuiJin Kong & Jie Wu & Hao Ying & HuanZhang Zhu, 2012. "Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0035020
    DOI: 10.1371/journal.pone.0035020
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