IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0033606.html
   My bibliography  Save this article

CSF-Biomarkers in Olympic Boxing: Diagnosis and Effects of Repetitive Head Trauma

Author

Listed:
  • Sanna Neselius
  • Helena Brisby
  • Annette Theodorsson
  • Kaj Blennow
  • Henrik Zetterberg
  • Jan Marcusson

Abstract

Background: Sports-related head trauma is common but still there is no established laboratory test used in the diagnostics of minimal or mild traumatic brain injuries. Further the effects of recurrent head trauma on brain injury markers are unknown. The purpose of this study was to investigate the relationship between Olympic (amateur) boxing and cerebrospinal fluid (CSF) brain injury biomarkers. Methods: The study was designed as a prospective cohort study. Thirty Olympic boxers with a minimum of 45 bouts and 25 non-boxing matched controls were included in the study. CSF samples were collected by lumbar puncture 1–6 days after a bout and after a rest period for at least 14 days. The controls were tested once. Biomarkers for acute and chronic brain injury were analysed. Results: NFL (mean ± SD, 532±553 vs 135±51 ng/L p = 0.001), GFAP (496±238 vs 247±147 ng/L p 80% of the boxers demonstrate that both the acute and the cumulative effect of head trauma in Olympic boxing may induce CSF biomarker changes that suggest minor central nervous injuries. The lack of normalization of NFL and GFAP after the rest period in a subgroup of boxers may indicate ongoing degeneration. The recurrent head trauma in boxing may be associated with increased risk of chronic traumatic brain injury.

Suggested Citation

  • Sanna Neselius & Helena Brisby & Annette Theodorsson & Kaj Blennow & Henrik Zetterberg & Jan Marcusson, 2012. "CSF-Biomarkers in Olympic Boxing: Diagnosis and Effects of Repetitive Head Trauma," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0033606
    DOI: 10.1371/journal.pone.0033606
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033606
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033606&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0033606?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mattias Vågberg & Niklas Norgren & Ann Dring & Thomas Lindqvist & Richard Birgander & Henrik Zetterberg & Anders Svenningsson, 2015. "Levels and Age Dependency of Neurofilament Light and Glial Fibrillary Acidic Protein in Healthy Individuals and Their Relation to the Brain Parenchymal Fraction," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-8, August.
    2. Alessandra Costanza & Michalina Radomska & Francesco Zenga & Andrea Amerio & Andrea Aguglia & Gianluca Serafini & Mario Amore & Isabella Berardelli & Yasutaka Ojio & Khoa D. Nguyen, 2021. "Severe Suicidality in Athletes with Chronic Traumatic Encephalopathy: A Case Series and Overview on Putative Ethiopathogenetic Mechanisms," IJERPH, MDPI, vol. 18(3), pages 1-15, January.
    3. Michail Ntikas & Ferdinand Binkofski & N. Jon Shah & Magdalena Ietswaart, 2022. "Repeated Sub-Concussive Impacts and the Negative Effects of Contact Sports on Cognition and Brain Integrity," IJERPH, MDPI, vol. 19(12), pages 1-15, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0033606. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.