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Transcriptomics Comparison between Porcine Adipose and Bone Marrow Mesenchymal Stem Cells during In Vitro Osteogenic and Adipogenic Differentiation

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  • Elisa Monaco
  • Massimo Bionaz
  • Sandra Rodriguez-Zas
  • Walter L Hurley
  • Matthew B Wheeler

Abstract

Bone-marrow mesenchymal stem cells (BMSC) are considered the gold standard for use in tissue regeneration among mesenchymal stem cells (MSC). The abundance and ease of harvest make the adipose-derived stem cells (ASC) an attractive alternative to BMSC. The aim of the present study was to compare the transcriptome of ASC and BMSC, respectively isolated from subcutaneous adipose tissue and femur of 3 adult pigs, during in vitro osteogenic and adipogenic differentiation for up to four weeks. At 0, 2, 7, and 21 days of differentiation RNA was extracted for microarray analysis. A False Discovery Rate ≤0.05 for overall interactions effect and P

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  • Elisa Monaco & Massimo Bionaz & Sandra Rodriguez-Zas & Walter L Hurley & Matthew B Wheeler, 2012. "Transcriptomics Comparison between Porcine Adipose and Bone Marrow Mesenchymal Stem Cells during In Vitro Osteogenic and Adipogenic Differentiation," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-19, March.
    • Handle: RePEc:plo:pone00:0032481
    DOI: 10.1371/journal.pone.0032481
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