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Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study)

Author

Listed:
  • Motoji Sawabe
  • Noriko Tanaka
  • Makiko Naka Mieno
  • Shizukiyo Ishikawa
  • Kazunori Kayaba
  • Ken-ichi Nakahara
  • Satoru Matsushita
  • J. M. S. Cohort Study Group

Abstract

Background: Experimental studies support the anti-neoplastic effect of apo(a), but several clinical studies have reported contradictory results. The purpose of this study was to determine whether a low lipoprotein(a) [Lp(a)] concentration is related to mortality from major causes of death, especially cancer. Methods: The subjects were 10,413 participants (4,005 men and 6,408 women) from a multi-center population-based cohort study in Japan (The Jichi Medical School cohort study). The average age at registration was 55.0 years, and the median observation period was 4,559 days. As the estimated hazard ratio was high for both the low and very high Lp(a) levels, we defined two Lp(a) groups: a low Lp(a) group [Lp(a)

Suggested Citation

  • Motoji Sawabe & Noriko Tanaka & Makiko Naka Mieno & Shizukiyo Ishikawa & Kazunori Kayaba & Ken-ichi Nakahara & Satoru Matsushita & J. M. S. Cohort Study Group, 2012. "Low Lipoprotein(a) Concentration Is Associated with Cancer and All-Cause Deaths: A Population-Based Cohort Study (The JMS Cohort Study)," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0031954
    DOI: 10.1371/journal.pone.0031954
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