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The Role of Circulating Serotonin in the Development of Chronic Obstructive Pulmonary Disease

Author

Listed:
  • Way K W Lau
  • Moira M W Chan-Yeung
  • Benjamin H K Yip
  • Amy H K Cheung
  • Mary S M Ip
  • Judith C W Mak
  • and the COPD Study Group of the Hong Kong Thoracic Society

Abstract

Background: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a significant mediator in this relationship. The interrelation between circulating serotonin (5-hydroxytyptamine, 5-HT), cigarette smoking and COPD is however largely unknown. The current study aimed at investigating the mediation effects of plasma 5-HT on cigarette smoking-induced COPD and the relation between plasma 5-HT levels and age. Methods: The association between plasma 5-HT, age and COPD was analyzed in a total of 62 COPD patients (ever-smokers) and 117 control subjects (healthy non-smokers and ever-smokers). Plasma 5-HT levels were measured by enzyme-linked immuno assay (EIA). Results: The elevated plasma 5-HT levels were significantly associated with increased odds for COPD (OR = 1.221, 95% CI = 1.123 to 1.319, p

Suggested Citation

  • Way K W Lau & Moira M W Chan-Yeung & Benjamin H K Yip & Amy H K Cheung & Mary S M Ip & Judith C W Mak & and the COPD Study Group of the Hong Kong Thoracic Society, 2012. "The Role of Circulating Serotonin in the Development of Chronic Obstructive Pulmonary Disease," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0031617
    DOI: 10.1371/journal.pone.0031617
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