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Association of Mitochondrial DNA Variations with Lung Cancer Risk in a Han Chinese Population from Southwestern China

Author

Listed:
  • Shizhen Zheng
  • Pin Qian
  • Fuxiang Li
  • Guisheng Qian
  • Changzheng Wang
  • Guoming Wu
  • Qi Li
  • Yan Chen
  • Jin Li
  • Haining Li
  • Binfeng He
  • Fuyun Ji

Abstract

Mitochondrial DNA (mtDNA) is particularly susceptible to oxidative damage and mutation due to the high rate of reactive oxygen species (ROS) production and limited DNA-repair capacity in mitochondrial. Previous studies demonstrated that the increased mtDNA copy number for compensation for damage, which was associated with cigarette smoking, has been found to be associated with lung cancer risk among heavy smokers. Given that the common and “non-pathological” mtDNA variations determine differences in oxidative phosphorylation performance and ROS production, an important determinant of lung cancer risk, we hypothesize that the mtDNA variations may play roles in lung cancer risk. To test this hypothesis, we conducted a case-control study to compare the frequencies of mtDNA haplogroups and an 822 bp mtDNA deletion between 422 lung cancer patients and 504 controls. Multivariate logistic regression analysis revealed that haplogroups D and F were related to individual lung cancer resistance (OR = 0.465, 95%CI = 0.329–0.656, p

Suggested Citation

  • Shizhen Zheng & Pin Qian & Fuxiang Li & Guisheng Qian & Changzheng Wang & Guoming Wu & Qi Li & Yan Chen & Jin Li & Haining Li & Binfeng He & Fuyun Ji, 2012. "Association of Mitochondrial DNA Variations with Lung Cancer Risk in a Han Chinese Population from Southwestern China," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-9, February.
    • Handle: RePEc:plo:pone00:0031322
    DOI: 10.1371/journal.pone.0031322
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