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Vitamin D Binding Protein and Monocyte Response to 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D: Analysis by Mathematical Modeling

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  • Rene F Chun
  • Bradford E Peercy
  • John S Adams
  • Martin Hewison

Abstract

Vitamin D binding protein (DBP) plays a key role in the bioavailability of active 1,25-dihydroxyvitamin D (1,25(OH)2D) and its precursor 25-hydroxyvitamin D (25OHD), but accurate analysis of DBP-bound and free 25OHD and 1,25(OH)2D is difficult. To address this, two new mathematical models were developed to estimate: 1) serum levels of free 25OHD/1,25(OH)2D based on DBP concentration and genotype; 2) the impact of DBP on the biological activity of 25OHD/1,25(OH)2D in vivo. The initial extracellular steady state (eSS) model predicted that 50 nM 25OHD and 100 pM 1,25(OH)2D),

Suggested Citation

  • Rene F Chun & Bradford E Peercy & John S Adams & Martin Hewison, 2012. "Vitamin D Binding Protein and Monocyte Response to 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D: Analysis by Mathematical Modeling," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-10, January.
    • Handle: RePEc:plo:pone00:0030773
    DOI: 10.1371/journal.pone.0030773
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