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DISC1 Conditioned GWAS for Psychosis Proneness in a Large Finnish Birth Cohort

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  • Liisa Tomppo
  • Jesper Ekelund
  • Dirk Lichtermann
  • Juha Veijola
  • Marjo-Riitta Järvelin
  • William Hennah

Abstract

Background: Genetic evidence implicates the DISC1 gene in the etiology of a number of mental illnesses. Previously, we have reported association between DISC1 and measures of psychosis proneness, the Revised Social Anhedonia Scale (RSAS) and Revised Physical Anhedonia Scale (RPAS), in the Northern Finland Birth Cohort 1966 (NFBC66). As part of the studies of this Finnish birth cohort genome-wide association analysis has recently been performed. Methodology: In the present study, we re-analyzed the genome-wide association data with regard to these two measures of psychosis proneness, conditioning on our previous DISC1 observation. From the original NFBC66 sample (N = 12 058), 4 561 individuals provided phenotype and genotype data. No markers were significant at the genome-wide level. However, several genes with biological relevance to mental illnesses were highlighted through loci displaying suggestive evidence for association (≥3 SNP with P

Suggested Citation

  • Liisa Tomppo & Jesper Ekelund & Dirk Lichtermann & Juha Veijola & Marjo-Riitta Järvelin & William Hennah, 2012. "DISC1 Conditioned GWAS for Psychosis Proneness in a Large Finnish Birth Cohort," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-5, February.
    • Handle: RePEc:plo:pone00:0030643
    DOI: 10.1371/journal.pone.0030643
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