IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0030337.html
   My bibliography  Save this article

Safety Issues of Long-Term Glucose Load in Patients on Peritoneal Dialysis—A 7-Year Cohort Study

Author

Listed:
  • Hon-Yen Wu
  • Kuan-Yu Hung
  • Tao-Min Huang
  • Fu-Chang Hu
  • Yu-Sen Peng
  • Jenq-Wen Huang
  • Shuei-Liong Lin
  • Yung-Ming Chen
  • Tzong-Shinn Chu
  • Tun-Jun Tsai
  • Kwan-Dun Wu

Abstract

Background: Effects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival. Methods: We surveyed 173 incident PD patients. Long-term glucose load was evaluated by calculating the average dialysate glucose concentration since initiation of PD. Risk factors were assessed by fitting Cox's models with repeatedly measured time-dependent covariates. Results: We noted that older age, higher glucose concentration, and lower residual renal function (RRF) were significantly associated with a worse patient survival. We found that female gender, absence of diabetes, lower glucose concentration, use of icodextrin, higher serum high density lipoprotein cholesterol, and higher RRF were significantly associated with a better technique survival. Conclusions: Long-term glucose load predicted mortality and technique failure in chronic PD patients. These findings emphasize the importance of minimizing glucose load in PD patients.

Suggested Citation

  • Hon-Yen Wu & Kuan-Yu Hung & Tao-Min Huang & Fu-Chang Hu & Yu-Sen Peng & Jenq-Wen Huang & Shuei-Liong Lin & Yung-Ming Chen & Tzong-Shinn Chu & Tun-Jun Tsai & Kwan-Dun Wu, 2012. "Safety Issues of Long-Term Glucose Load in Patients on Peritoneal Dialysis—A 7-Year Cohort Study," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    • Handle: RePEc:plo:pone00:0030337
    DOI: 10.1371/journal.pone.0030337
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030337
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030337&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0030337?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0030337. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.