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Liver Enzymes: Interaction Analysis of Smoking with Alcohol Consumption or BMI, Comparing AST and ALT to γ-GT

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  • Lutz P Breitling
  • Volker Arndt
  • Christoph Drath
  • Hermann Brenner

Abstract

Background: A detrimental interaction between smoking and alcohol consumption with respect serum γ-glutamyltransferase (γ-GT) has recently been described. The underlying mechanisms remain unknown. The present work aimed to provide further insights by examining similar interactions pertaining to aspartate and alanine transaminase (AST, ALT), routine liver markers less prone to enzyme induction. Methodology/Principal Findings: The present cross-sectional analysis was based on records from routine occupational health examinations of 15,281 male employees predominantly of the construction industry, conducted from 1986 to 1992 in Southern Germany. Associations of smoking intensity with log-transformed activities of γ-GT, AST, and ALT were examined in regression models adjusted for potential confounders and including an interaction of smoking with alcohol consumption or body mass index (BMI). Statistically significant interactions of smoking were observed with both alcohol consumption (AST and ALT, each with P

Suggested Citation

  • Lutz P Breitling & Volker Arndt & Christoph Drath & Hermann Brenner, 2011. "Liver Enzymes: Interaction Analysis of Smoking with Alcohol Consumption or BMI, Comparing AST and ALT to γ-GT," PLOS ONE, Public Library of Science, vol. 6(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0027951
    DOI: 10.1371/journal.pone.0027951
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    1. Lutz P Breitling & Volker Arndt & Christoph Drath & Dietrich Rothenbacher & Hermann Brenner, 2010. "Smoking and γ-Glutamyltransferase: Opposite Interactions with Alcohol Consumption and Body Mass Index," PLOS ONE, Public Library of Science, vol. 5(9), pages 1-9, September.
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