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Serum A-FABP Is Increased and Closely Associated with Elevated NT-proBNP Levels in Type 2 Diabetic Patients Treated with Rosiglitazone

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  • Mi Zhou
  • Yuqian Bao
  • Junxi Lu
  • Jian Zhou
  • Weiping Jia

Abstract

Background: Adipocyte fatty acid-binding protein (A-FABP) has been shown to play important roles in the development of metabolic syndrome, diabetes, and cardiovascular diseases. In this study we investigated the possible role of A-FABP in the development of cardiac dysfunction related to rosiglitazone treatment. Methodology/Principal Findings: A total of 84 patients with newly diagnosed type 2 diabetes were treated with rosiglitazone for 48 weeks. Circulating A-FABP and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were determined at baseline and repeated at 24 and 48 weeks. After the 48-week rosiglitazone treatment period, serum levels of both A-FABP and NT-proBNP increased progressively and significantly (P

Suggested Citation

  • Mi Zhou & Yuqian Bao & Junxi Lu & Jian Zhou & Weiping Jia, 2011. "Serum A-FABP Is Increased and Closely Associated with Elevated NT-proBNP Levels in Type 2 Diabetic Patients Treated with Rosiglitazone," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0027032
    DOI: 10.1371/journal.pone.0027032
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