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Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

Author

Listed:
  • Verena Bihrer
  • Oliver Waidmann
  • Mireen Friedrich-Rust
  • Nicole Forestier
  • Simone Susser
  • Jörg Haupenthal
  • Martin Welker
  • Ying Shi
  • Jan Peveling-Oberhag
  • Andreas Polta
  • Michael von Wagner
  • Heinfried H Radeke
  • Christoph Sarrazin
  • Jörg Trojan
  • Stefan Zeuzem
  • Bernd Kronenberger
  • Albrecht Piiper

Abstract

Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC. Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P

Suggested Citation

  • Verena Bihrer & Oliver Waidmann & Mireen Friedrich-Rust & Nicole Forestier & Simone Susser & Jörg Haupenthal & Martin Welker & Ying Shi & Jan Peveling-Oberhag & Andreas Polta & Michael von Wagner & He, 2011. "Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0026971
    DOI: 10.1371/journal.pone.0026971
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