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Outcome Prediction in Pneumonia Induced ALI/ARDS by Clinical Features and Peptide Patterns of BALF Determined by Mass Spectrometry

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  • Jochen Frenzel
  • Christian Gessner
  • Torsten Sandvoss
  • Stefan Hammerschmidt
  • Wolfgang Schellenberger
  • Ulrich Sack
  • Klaus Eschrich
  • Hubert Wirtz

Abstract

Background: Peptide patterns of bronchoalveolar lavage fluid (BALF) were assumed to reflect the complex pathology of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) better than clinical and inflammatory parameters and may be superior for outcome prediction. Methodology/Principal Findings: A training group of patients suffering from ALI/ARDS was compiled from equal numbers of survivors and nonsurvivors. Clinical history, ventilation parameters, Murray's lung injury severity score (Murray's LISS) and interleukins in BALF were gathered. In addition, samples of bronchoalveolar lavage fluid were analyzed by means of hydrophobic chromatography and MALDI-ToF mass spectrometry (MALDI-ToF MS). Conclusions/Significance: MALDI-ToF MS peptide patterns of BALF, evaluated by appropriate mathematical methods can be of value in predicting outcome in pneumonia induced ALI/ARDS.

Suggested Citation

  • Jochen Frenzel & Christian Gessner & Torsten Sandvoss & Stefan Hammerschmidt & Wolfgang Schellenberger & Ulrich Sack & Klaus Eschrich & Hubert Wirtz, 2011. "Outcome Prediction in Pneumonia Induced ALI/ARDS by Clinical Features and Peptide Patterns of BALF Determined by Mass Spectrometry," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0025544
    DOI: 10.1371/journal.pone.0025544
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