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Impact of Genetic Variation in SORCS1 on Memory Retention

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  • Christiane Reitz
  • Joseph H Lee
  • Robert S Rogers
  • Richard Mayeux

Abstract

Objective: We previously reported that genetic variants in SORCS1 increase the risk of AD, that over-expression of SorCS1 reduces γ-secretase activity and Aβ levels, and that SorCS1 suppression increases γ-secretase processing of APP and Aβ levels. We now explored the effect of variation in SORCS1 on memory. Methods: We explored associations between SORCS1-SNPs and memory retention in the NIA-LOAD case control dataset (162 cases,670 controls) and a cohort of Caribbean Hispanics (549 cases,544 controls) using single marker and haplotype analyses. Results: Three SNPs in intron 1, were associated with memory retention in the NIA-LOAD dataset or the Caribbean Hispanic dataset (rs10884402(A allele:β = −0.15,p = 0.008), rs7078098(C allele:β = 0.18,p = 0.007) and rs950809(C allele:β = 0.17,p = 0.008)) and all three SNPs were significant in a meta-analysis of both datasets (0.002

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  • Christiane Reitz & Joseph H Lee & Robert S Rogers & Richard Mayeux, 2011. "Impact of Genetic Variation in SORCS1 on Memory Retention," PLOS ONE, Public Library of Science, vol. 6(10), pages 1-6, October.
    • Handle: RePEc:plo:pone00:0024588
    DOI: 10.1371/journal.pone.0024588
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