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Analysis of Factors Lowering Sensitivity of Interferon-γ Release Assay for Tuberculosis

Author

Listed:
  • Nguyen Thi Le Hang
  • Luu Thi Lien
  • Nobuyuki Kobayashi
  • Takuro Shimbo
  • Shinsaku Sakurada
  • Pham Huu Thuong
  • Le Thi Hong
  • Do Bang Tam
  • Minako Hijikata
  • Ikumi Matsushita
  • Nguyen Van Hung
  • Kazue Higuchi
  • Nobuyuki Harada
  • Naoto Keicho

Abstract

Background: Imperfect sensitivity of interferon-γ release assay (IGRA) is a potential problem to detect tuberculosis. We made a thorough investigation of the factors that can lead to false negativity of IGRA. Methods: We recruited 543 patients with new smear-positive pulmonary tuberculosis in Hanoi, Viet Nam. At diagnosis, peripheral blood was collected and IGRA (QuantiFERON-TB Gold In-Tube) was performed. Clinical and epidemiological information of the host and pathogen was collected. The test sensitivity was calculated and factors negatively influencing IGRA results were evaluated using a logistic regression model in 504 patients with culture-confirmed pulmonary tuberculosis. Results: The overall sensitivity of IGRA was 92.3% (95% CI, 89.6%–94.4%). The proportions of IGRA-negative and -indeterminate results were 4.8% (95% CI, 3.1%–7.0%) and 3.0% (95% CI, 1.7%–4.9%). Age increased by year, body mass index

Suggested Citation

  • Nguyen Thi Le Hang & Luu Thi Lien & Nobuyuki Kobayashi & Takuro Shimbo & Shinsaku Sakurada & Pham Huu Thuong & Le Thi Hong & Do Bang Tam & Minako Hijikata & Ikumi Matsushita & Nguyen Van Hung & Kazue , 2011. "Analysis of Factors Lowering Sensitivity of Interferon-γ Release Assay for Tuberculosis," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0023806
    DOI: 10.1371/journal.pone.0023806
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