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Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis

Author

Listed:
  • James F Meschia
  • Andrew Singleton
  • Michael A Nalls
  • Stephen S Rich
  • Pankaj Sharma
  • Luigi Ferrucci
  • Mar Matarin
  • Dena G Hernandez
  • Kerra Pearce
  • Thomas G Brott
  • Robert D Brown Jr.
  • John Hardy
  • Bradford B Worrall

Abstract

Introduction: Familial aggregation of ischemic stroke derives from shared genetic and environmental factors. We present a meta-analysis of genome-wide association scans (GWAS) from 3 cohorts to identify the contribution of common variants to ischemic stroke risk. Methods: This study involved 1464 ischemic stroke cases and 1932 controls. Cases were genotyped using the Illumina 610 or 660 genotyping arrays; controls, with Illumina HumanHap 550Kv1 or 550Kv3 genotyping arrays. Imputation was performed with the 1000 Genomes European ancestry haplotypes (August 2010 release) as a reference. A total of 5,156,597 single-nucleotide polymorphisms (SNPs) were incorporated into the fixed effects meta-analysis. All SNPs associated with ischemic stroke (P

Suggested Citation

  • James F Meschia & Andrew Singleton & Michael A Nalls & Stephen S Rich & Pankaj Sharma & Luigi Ferrucci & Mar Matarin & Dena G Hernandez & Kerra Pearce & Thomas G Brott & Robert D Brown Jr. & John Hard, 2011. "Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0023161
    DOI: 10.1371/journal.pone.0023161
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