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Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients

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  • Damiano Gullo
  • Adele Latina
  • Francesco Frasca
  • Rosario Le Moli
  • Gabriella Pellegriti
  • Riccardo Vigneri

Abstract

Context: Levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral T4 to T3 conversion is believed to account for the overall tissue requirement for thyroid hormones. However, there are indirect evidences that this may not be the case in all patients. Objective: To evaluate in a large series of athyreotic patients whether levothyroxine monotherapy can normalize serum thyroid hormones and thyroid-pituitary feedback. Design: Retrospective study. Setting: Academic hospital. Patients: 1,811 athyreotic patients with normal TSH levels under levothyroxine monotherapy and 3,875 euthyroid controls. Measurements: TSH, FT4 and FT3 concentrations by immunoassays. Results: FT4 levels were significantly higher and FT3 levels were significantly lower (p

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  • Damiano Gullo & Adele Latina & Francesco Frasca & Rosario Le Moli & Gabriella Pellegriti & Riccardo Vigneri, 2011. "Levothyroxine Monotherapy Cannot Guarantee Euthyroidism in All Athyreotic Patients," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-7, August.
  • Handle: RePEc:plo:pone00:0022552
    DOI: 10.1371/journal.pone.0022552
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    Cited by:

    1. Georges Hajje & Youakim Saliba & Tarek Itani & Majed Moubarak & Georges Aftimos & Nassim Farès, 2014. "Hypothyroidism and Its Rapid Correction Alter Cardiac Remodeling," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-13, October.

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