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Improving the Characterization of Radiologically Isolated Syndrome Suggestive of Multiple Sclerosis

Author

Listed:
  • Nicola De Stefano
  • Maria Laura Stromillo
  • Francesca Rossi
  • Marco Battaglini
  • Antonio Giorgio
  • Emilio Portaccio
  • Bahia Hakiki
  • Gianmichele Malentacchi
  • Claudio Gasperini
  • Mario Santangelo
  • Maria Letizia Bartolozzi
  • Maria Pia Sormani
  • Antonio Federico
  • Maria Pia Amato

Abstract

Objective: To improve the characterization of asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a condition named as “radiologically isolated syndrome” (RIS). Methods: Quantitative MRI metrics such as brain volumes and magnetization transfer (MT) were assessed in 19 subjects previously classified as RIS, 20 demographically-matched relapsing-remitting MS (RRMS) patients and 20 healthy controls (HC). Specific measures were: white matter (WM) lesion volumes (LV), total and regional brain volumes, and MT ratio (MTr) in lesions, normal-appearing WM (NAWM) and cortex. Results: LV was similar in RIS and RRMS, without differences in distribution and frequency at lesion mapping. Brain volumes were similarly lower in RRMS and RIS than in HC (p

Suggested Citation

  • Nicola De Stefano & Maria Laura Stromillo & Francesca Rossi & Marco Battaglini & Antonio Giorgio & Emilio Portaccio & Bahia Hakiki & Gianmichele Malentacchi & Claudio Gasperini & Mario Santangelo & Ma, 2011. "Improving the Characterization of Radiologically Isolated Syndrome Suggestive of Multiple Sclerosis," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-9, April.
    • Handle: RePEc:plo:pone00:0019452
    DOI: 10.1371/journal.pone.0019452
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