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Identification of C16orf74 as a Marker of Progression in Primary Non-Muscle Invasive Bladder Cancer

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Listed:
  • Won Tae Kim
  • Seok Joong Yun
  • Cheol Park
  • Isaac Yi Kim
  • Sung-Kwon Moon
  • Tae Gyun Kwon
  • Yung Hyun Choi
  • Wun-Jae Kim

Abstract

Purpose: Methylation-induced silencing of PRSS3 has been shown to be significantly associated with invasive bladder cancer, and expression of the C16orf74 gene locus has been shown to correlate positively with PRSS3. The aim of the current study was to evaluate the relationship between C16orf74 expression level and progression in non-muscle invasive bladder cancer (NMIBC). Materials and Methods: C16orf74 mRNA levels were examined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis of 193 tumor specimens from patients with primary NMIBC. Expression data were analyzed in terms of clinical and experimental parameters. Kaplan-Meier curves and multivariate Cox regression models, respectively, were used to determine progression-free survival and to identify independent predictive parameters of progression. Results: Analysis using Kaplan-Meier curves revealed prolonged progression-free survival of high-C16orf74-expressors as compared to low-expressors (p

Suggested Citation

  • Won Tae Kim & Seok Joong Yun & Cheol Park & Isaac Yi Kim & Sung-Kwon Moon & Tae Gyun Kwon & Yung Hyun Choi & Wun-Jae Kim, 2010. "Identification of C16orf74 as a Marker of Progression in Primary Non-Muscle Invasive Bladder Cancer," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-5, December.
    • Handle: RePEc:plo:pone00:0015260
    DOI: 10.1371/journal.pone.0015260
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