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Essential Role of NMDA Receptor Channel ε4 Subunit (GluN2D) in the Effects of Phencyclidine, but Not Methamphetamine

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  • Yoko Hagino
  • Shinya Kasai
  • Wenhua Han
  • Hideko Yamamoto
  • Toshitaka Nabeshima
  • Masayoshi Mishina
  • Kazutaka Ikeda

Abstract

Phencyclidine (PCP), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, increases locomotor activity in rodents and causes schizophrenia-like symptoms in humans. Although activation of the dopamine (DA) pathway is hypothesized to mediate these effects of PCP, the precise mechanisms by which PCP induces its effects remain to be elucidated. The present study investigated the effect of PCP on extracellular levels of DA (DAex) in the striatum and prefrontal cortex (PFC) using in vivo microdialysis in mice lacking the NMDA receptor channel ε1 or ε4 subunit (GluRε1 [GluN2A] or GluRε4 [GluN2D]) and locomotor activity. PCP significantly increased DAex in wildtype and GluRε1 knockout mice, but not in GluRε4 knockout mice, in the striatum and PFC. Acute and repeated administration of PCP did not increase locomotor activity in GluRε4 knockout mice. The present results suggest that PCP enhances dopaminergic transmission and increases locomotor activity by acting at GluRε4.

Suggested Citation

  • Yoko Hagino & Shinya Kasai & Wenhua Han & Hideko Yamamoto & Toshitaka Nabeshima & Masayoshi Mishina & Kazutaka Ikeda, 2010. "Essential Role of NMDA Receptor Channel ε4 Subunit (GluN2D) in the Effects of Phencyclidine, but Not Methamphetamine," PLOS ONE, Public Library of Science, vol. 5(10), pages 1-7, October.
    • Handle: RePEc:plo:pone00:0013722
    DOI: 10.1371/journal.pone.0013722
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