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Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype

Author

Listed:
  • Andrea von Groll
  • Anandi Martin
  • Matthias Stehr
  • Mahavir Singh
  • Françoise Portaels
  • Pedro Eduardo Almeida da Silva
  • Juan Carlos Palomino

Abstract

Background: Multidrug resistant tuberculosis (MDR-TB) is a major threat for global tuberculosis control. The W-Beijing Mycobacterium tuberculosis genotype has been associated with drug resistance. Elucidation of the mechanisms underlying this epidemiological finding may have an important role in the control of MDR-TB. The aim of this study was to evaluate the fitness of drug-susceptible and MDR M. tuberculosis strains of the W-Beijing genotype compared with that of Non-W-Beijing strains. Methodology/Principal Findings: Fitness of M. tuberculosis strains was determined by evaluating the difference in the growth curves obtained in the MGIT960 automated system and assessing the competitive growth capacity between W-Beijing and non-W-Beijing strains. The W-Beijing MDR strains had a significant longer lag phase duration compared to the other strains but did not present a significant fitness cost. When grown in competition they had an advantage only in medium containing 0.1% Tween 80. Conclusions/Significance: It was not possible to confirm a selective advantage of W-Beijing strains to grow, except for differences in their resistance to Tween 80. Further studies are needed to elucidate the putative advantage of W-Beijing strains compared to other genotypes.

Suggested Citation

  • Andrea von Groll & Anandi Martin & Matthias Stehr & Mahavir Singh & Françoise Portaels & Pedro Eduardo Almeida da Silva & Juan Carlos Palomino, 2010. "Fitness of Mycobacterium tuberculosis Strains of the W-Beijing and Non-W-Beijing Genotype," PLOS ONE, Public Library of Science, vol. 5(4), pages 1-6, April.
    • Handle: RePEc:plo:pone00:0010191
    DOI: 10.1371/journal.pone.0010191
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