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Variation at GRN 3′-UTR rs5848 Is Not Associated with a Risk of Frontotemporal Lobar Degeneration in Dutch Population

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Listed:
  • Javier Simón-Sánchez
  • Harro Seelaar
  • Zoltán Bochdanovits
  • Dorly J H Deeg
  • John C van Swieten
  • Peter Heutink

Abstract

Background: A single nucleotide polymorphism (rs5848) located in the 3′- untranslated region of GRN has recently been associated with a risk of frontotemporal lobar degeneration (FTLD) in North American population particularly in pathologically confirmed cases with neural inclusions immunoreactive for ubiquitin and TAR DNA-binding protein 43 (TDP-43), but negative for tau and alpha-synuclein (FTLD-TDP). Methodology/Principal Findings: In an effort to replicate these results in a different population, rs5848 was genotyped in 256 FTLD cases and 1695 controls from the Netherlands. Single SNP gender-adjusted logistic regression analysis revealed no significant association between variation at rs5848 and FTLD. Fisher's exact test, failed to find any significant association between rs5848 and a subset of 23 pathology confirmed FTLD-TDP cases. Conclusions/Significance: The evidence presented here suggests that variation at rs5848 does not contribute to the etiology of FTLD in the Dutch population.

Suggested Citation

  • Javier Simón-Sánchez & Harro Seelaar & Zoltán Bochdanovits & Dorly J H Deeg & John C van Swieten & Peter Heutink, 2009. "Variation at GRN 3′-UTR rs5848 Is Not Associated with a Risk of Frontotemporal Lobar Degeneration in Dutch Population," PLOS ONE, Public Library of Science, vol. 4(10), pages 1-4, October.
    • Handle: RePEc:plo:pone00:0007494
    DOI: 10.1371/journal.pone.0007494
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