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Calprotectin — A Novel Marker of Obesity

Author

Listed:
  • Ole Hartvig Mortensen
  • Anders Rinnov Nielsen
  • Christian Erikstrup
  • Peter Plomgaard
  • Christian Philip Fischer
  • Rikke Krogh-Madsen
  • Birgitte Lindegaard
  • Anne Marie Petersen
  • Sarah Taudorf
  • Bente Klarlund Pedersen

Abstract

Background: The two inflammatory molecules, S100A8 and S100A9, form a heterodimer, calprotectin. Plasma calprotectin levels are elevated in various inflammatory disorders. We hypothesized that plasma calprotectin levels would be increased in subjects with low-grade systemic inflammation i.e. either obese subjects or subjects with type 2 diabetes. Methodology/Principal Findings: Plasma calprotectin and skeletal muscle S100A8 mRNA levels were measured in a cohort consisting of 199 subjects divided into four groups depending on presence or absence of type 2 diabetes (T2D), and presence or absence of obesity. There was a significant interaction between obesity and T2D (p = 0.012). Plasma calprotectin was increased in obese relative to non-obese controls (p

Suggested Citation

  • Ole Hartvig Mortensen & Anders Rinnov Nielsen & Christian Erikstrup & Peter Plomgaard & Christian Philip Fischer & Rikke Krogh-Madsen & Birgitte Lindegaard & Anne Marie Petersen & Sarah Taudorf & Bent, 2009. "Calprotectin — A Novel Marker of Obesity," PLOS ONE, Public Library of Science, vol. 4(10), pages 1-4, October.
    • Handle: RePEc:plo:pone00:0007419
    DOI: 10.1371/journal.pone.0007419
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